Project Description

Name

Dihexa
[CAS]

1401708-83-5
[Synonyms]

Dihexa
PNB-0408
Dihexa (PNB-0408)
Hexanoyl-Tyr-Ile-Ahx-NH2
N-hexanoic-Try-Ile-(6)-amino hexanoic amide
N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE
L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-
[EINECS(EC#)]

227-005-2
[Molecular Formula]

C27H44N4O5
[MOL File]

1401708-83-5.mol
[Molecular Weight]

504.66

Boiling point ]

866.2±65.0 °C(Predicted)
[density ]

1.111±0.06 g/cm3(Predicted)
[pka]

9.83±0.15(Predicted)

[Description]

Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer’s disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
[Uses]

Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease.